Increased sperm mitochondrial DNA content in male infertility

Increased sperm mitochondrial DNA content in male infertility.

BACKGROUND There is increasing evidence that mitochondrial DNA (mtDNA) anomalies in sperm may lead to infertility. Point mutations, deletions and the presence of a specific mtDNA haplogroup have been associated with poor sperm quality, but little attention has been paid to the role of mtDNA content. METHODS Using density gradient separation and swim-up methods, we selected motile sperm from 3...

Mitochondrial DNA mutations and male infertility

Infertility can be defined as difficulty in conceiving a child after 1 year of unprotected intercourse. Infertility can arise either because of the male factor or female factor or both. According to the current estimates, 15% of couples attempting their first pregnancy could not succeed. Infertility is either primary or secondary. Mitochondria have profound effect on all biochemical pathways, i...

Finding the fit: sperm DNA integrity testing for male infertility

The role of sperm DNA testing on male infertility

Implications of ejaculatory sperm DNA fragmentation on male infertility management